Sci. Maier, A. in The Central European Magdalenian 81180 https://doi.org/10.1007/978-94-017-7206-8_6 (Springer, 2015). 6 and Supplementary Fig. Were dedicated to providing you the best ofNews, with a focus on dependability andBusiness. 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If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. If you are interested in the full curriculum offered on our platform or would like to enroll in a more extensive career track, consider continuing your data science journey with one of our subscription plans today! a, The genetic ancestry of hunter-gatherers dated between 14ka and 5.2ka modelled using qpAdm, with Oberkassel, Yuzhniy Oleniy Ostrov, Goyet Q-2 and Neolithic farmers from present-day Turkey (Barcn, Mentee and Boncuklu sites) representing Oberkassel (WHG) (blue), Sidelkino (EHG) (red), GoyetQ2 (orange) and Anatolian Neolithic farmer (green) ancestries, respectively. and H. Ringbauer developed the contamination-estimation method. The Italian peninsula was previously considered to be another climatic refugium for humans during the LGM. 7 Admixture dates between Oberkassel/Villabruna and ANE ancestries in the oldest individuals from the Sidelkino cluster. Early Alpine occupation backdates westward human migration in Late Glacial Europe. Big data data warehousing and data science are two sub-tasks of a larger endeavor called data science, which is a sub-tasks of data science. 4 and Supplementary Data 3.C). Tina Huang is a Data Scientist at a FAANG (Facebook, Amazon Apple, Netflix, Google) company. A series of f4-symmetry statistics confirm that all the Epigravettian-associated individuals are cladal, and do not share excess affinity with any local (Paglicci 12) or non-local preceding ancestries (Goyet Q116-1, Kostenki 14, Malta 1 or Vstonice) (Supplementary Data 2.F). TV Actress. Its no surprise that she was selected for the Code Cup, a yearly event where students from all over the world compete in coding challenges. To determine the Y-chromosome haplogroups of male individuals, we genotyped the Y-chromosome reads using a Y-SNP list (v.15.73) from the International Society of Genetic Genealogy (ISOGG) dataset, ignoring C-to-T and G-to-A transitions on the forward and reverse reads, respectively. The hunter-gatherers were grouped based on their geographic origins and dates (Supplementary Information, section5). This might have been in part triggered by the concomitant expansion of Neolithic farmers across Europe and/or by environmental factors, such as the climatic event around 8.2ka, the largest abrupt cooling in the northern hemisphere during the Holocene epoch46,47. Samples with a percentage of human DNA in shotgun data around 0.1% or greater were enriched for a set of 1,237,207 targeted SNPs (1240k capture) across the human genome6. Commun. However, the genetic profile of contemporaneous Gravettian-associated individuals from western Europe remains unknown, as is their contribution to populations after the LGM. In conclusion, our study reveals that western and southwestern Europe served as climatic refugia for the persistence of human groups during the coldest phase of the last Ice Age whereas populations in the Italian peninsula and the eastern European plain were genetically overturned, challenging the role of these regions as glacial refugia for humans. Straus, L. G. The human occupation of southwestern Europe during the Last Glacial Maximum: Solutrean cultural adaptations in France and Iberia. In this video, I had the opportunity to talk with Tina Huang, a Data Scientist at one of the FAANG companies. Data Professor - How to Become a Data Scientist at FAANG - Facebook Commun. Nat. & Banks, W. E. in Les Socits Gravettiennes du Nord-Ouest Europen: Nouveaux Sites, Nouvelles Donnes, Nouvelles Lectures (eds Touz, O., Goutas, N., Salomon, H. & Noiret, P.) 323266 (Presses Univ. . Tina Huang | Continuing Studies at UVic "We find that individuals associated with a later culture, the Epigravettian, are genetically distinct from the area's previous inhabitants," says co-author He Yu. ADS No, there are no prerequisites for enrolling. 40, e3 (2012). Advanced Science: Vol 10, No 7 - onlinelibrary.wiley.com The PCA was calculated with 1379 individuals from 87 western Eurasian modern populations on the 1240k_HO dataset, which was intersected between the 1240k and Human Origins datasets (Supplementary Data 1.K). In addition to her data science work, Tina has also created the popular popular game Code Wars. Curr. Tina Huang is a statistician who focuses on the statistical modeling and analysis of big data. Dabney, J. et al. 2022 Fab Business Solutions - All Rights Reserved. Philos. Tina Huang Data Scientist. Jones, E. R. et al. C. Posth, H.Y., A.G., A.B.R., W.H. (eds. (black) or 3s.e.m. Palma di Cesnola, A. Tina Huang: Xiamen Guansheng Precision Machinery Co Ltd is a Kumar, S., Stecher, G., Li, M., Knyaz, C. & Tamura, K. MEGA X: molecular evolutionary genetics analysis across computing platforms. Laplace, G. Essai de Typologie Systmatique (Annali dellUniversit di Ferrara, 1964). Res. An equimolar pool of all libraries was then prepared for shotgun sequencing on Illumina Hiseq4000 platform using 75bp single-end reads for screening. The pairwise f2 distance matrix of Epigravettian-associated groups was generated with qpfstats 200 in ADMIXTOOLS 7.0.2 package, with parameters allsnps: YES, scale: NO, and Mbuti.DG set as the outgroup. Epoxy Flooring UAE; Floor Coating UAE; Self Leveling Floor Coating; Wood Finishes and Coating; Functional Coatings. Instead, for the two SNPs associated with skin colour (SLC24A5 (rs1426654) and SLC45A2 (rs16891982)), Sidelkino clusterand Ukraine HG groups show a higher frequency (>90% for SLC24A5 and 2961% for SLC45A2) of the derived alleles related to light skin colour, compared with Oberkassel and Villabruna clusters, where those alleles are almost completely absent (<1%). She then pursued a Masters . Lifetime access to all course materials and updates. Save my name, email, and website in this browser for the next time I comment. Development of antifouling membrane film for treatment of oil-rich 6, 16581668 (2022). We identify a genetic ancestry profile in individuals associated with Upper Palaeolithic Gravettian assemblages from western Europe that is distinct from contemporaneous groups related to this archaeological culture in central and southern Europe4, but resembles that of preceding individuals associated with the Aurignacian culture. I hold a Bachelors degree at the University of Toronto where I studied pharmacology. An improved, lightweight and secure authentication scheme in context of fog-centric IoT communication is proposed in this paper to eradicate all the above mentioned security shortfalls of Wajid et al scheme. Resurrected Supernova Provides Missing-Link, Bald Eagles Aren't Fledging as Many Chicks, Ultracool Dwarf Binary Stars Break Records, Deflecting Asteroids to Protect Planet Earth, Quantum Chemistry: Molecules Caught Tunneling, Shark from Jurassic Period Highly Evolved, 2.9-Million-Year-Old Butchery Site Reopens Case of Who Made First Stone Tools, Gut Microbes Can Boost the Motivation to Exercise, Warmer Climate May Drive Fungi to Be More Dangerous to Our Health, Seawater Split to Produce 'Green' Hydrogen. Total students. Youll be surprised how much value there is in a quick XGBoost model, for example. Xiamen Guansheng Precision Machinery Co Ltd is a company integrating R&D, production and sales. Tina Huang (@hellotinah) / Twitter 537, 2432 (2020). F-statistics suggest that Le Piage II is genetically intermediate between Fournol 85 and El Mirn (Supplementary Data 2.D). The data here can also be structured or unstructured. These authors contributed equally: Cosimo Posth, He Yu, Archaeo- and Palaeogenetics, Institute for Archaeological Sciences, Department of Geosciences, University of Tbingen, Tbingen, Germany, Senckenberg Centre for Human Evolution and Palaeoenvironment at the University of Tbingen, Tbingen, Germany, Cosimo Posth,Dorothe G. Drucker,Herv Bocherens,Christoph Wiing,Nicholas J. Conard&Katerina Harvati, Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany, Cosimo Posth,He Yu,Ayshin Ghalichi,Hlne Rougier,Yilei Huang,Harald Ringbauer,Adam B. Rohrlach,Kathrin Ngele,Vanessa Villalba-Mouco,Rita Radzeviciute,Tiago Ferraz,Alexander Stoessel,Rezeda Tukhbatova,Wolfgang Haak&Johannes Krause, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China, Department of Anthropology, California State University Northridge, Northridge, CA, USA, Universit de Bordeaux, CNRS, MC, PACEA UMR 5199, Pessac, France, Isabelle Crevecoeur,Andr Morala,Stphane Madelaine,Priscilla Bayle,Bruno Maureille,Jean-Guillaume Bordes&Mona Le Luyer, School of Mathematical Sciences, University of Adelaide, Adelaide, South Australia, Australia, Instituto Universitario de Investigacin en Ciencias Ambientales de Aragn, IUCA-Aragosaurus, Zaragoza, Spain, Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany, Institute of Zoology and Evolutionary Research, University of Jena, Jena, Germany, Center of Excellence Archaeometry, Kazan Federal University, Kazan, Russia, Department of Biology, University of Florence, Florence, Italy, Martina Lari,Alessandra Modi&Stefania Vai, Estonian Biocentre, Institute of Genomics, University of Tartu, Tartu, Estonia, Tina Saupe,Christiana L. Scheib&Luca Pagani, St Johns College, University of Cambridge, Cambridge, UK, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy, Department of Biology, University of Padova, Padova, Italy, Department of Chemistry G. Ciamician, Alma Mater Studiorum, University of Bologna, Bologna, Italy, Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany, UMR 8068 CNRS, TEMPSTechnologie et Ethnologie des Mondes Prhistoriques, Nanterre Cedex, France, Laurent Klaric,Olivier Bignon-Lau,Grgory Debout,Michel Orliac,Pierre Bodu,Bndicte Souffi&Frdrique Valentin, Muse National de Prhistoire, Les Eyzies de Tayac, France, UMR 5140 CNRS, Archologie des Socits Mditerranennes, Universit Paul-Valry, Montpellier, France, UMR 7194, Histoire Naturelle de lHomme Prhistorique (HNHP), Dpartement Homme et Environnement, Musum National dHistoire Naturelle, CNRS, UPVD, Paris, France, Association APRAGE (Approches pluridisciplinaires de recherche archologique du Grand-Est), Besanon, France, Skeletal Biology Research Centre, School of Anthropology and Conservation, University of Kent, Canterbury, UK, Dipartimento di Scienze Fisiche, della Terra e dellAmbiente, U.R. Tina Huang. Paradis, E., Claude, J. Furthermore, we examined whether the patient's age, the etiology of their hearing loss, the depth of the electrode insertion, and a slow electrode insertion affect the result of postoperative speech audiometry (PSA). Pseudo-haploid genotypes were called on the targeted SNPs by randomly sampling a single allele at each position, resulting in individuals with 6,600 to 1.07 million SNPs covered on the 1.24-million-SNP panel (Extended Data Table 1 and Supplementary Data 1.A). Extended Data Fig. Publication: Huang T, Reimand J. Network-rewiring mutation in kinase signaling networks are informative of cancer patient. Fu, Q. et al. How to Become a Data Scientist at FAANG (Ft. Tina Huang) - Morioh It just raised $12.2 million. After another MinElute purification, the product was quantified using the Agilent 2100 Bioanalyzer DNA 1000 chip. Tina Huang, a data scientist currently working at a FAANG (Facebook, Amazon, Apple, Netflix, and Google Alphabet) company. wrote the manuscript with input from T.T., E.A., W.H., J. Krause and all other co-authors. Publications. Tina's authentic and engaging delivery style allows her to create original content on topics like how to be more productive, how to learn more efficiently, how to land a job in data science . 38. 1 and names are indicated next to the symbols. 1c and Extended Data Fig. These data suggest that the genetic ancestries identified in the pre-40ka individuals analysed so far went largely extinct or were assimilated by subsequent expansions1,9. Empleos Personas Learning . Questions? C.L.S. I Agree, Brandwatch Bulletin #41: 7 Women in Tech You ShouldKnow. The observation that post-14ka individuals from western and central Europe andalso from Britain41 carry a homogeneous genetic makeup instead of displaying repeated local admixtures with GoyetQ2 ancestry implies that the Oberkassel-ancestry profile was already largely formed before its dispersal. B 370, 20130624 (2015). Ancient genomes show social and reproductive behavior of early Upper Paleolithic foragers. The genetic affinity to the Villabruna ancestry is present in El Mirn and in Magdalenian-associated individuals from western and central Europe. Conversely, we reveal a genetic turnover in southern Europe suggesting a local replacement of human groups around the time of the Last Glacial Maximum, accompanied by a north-to-south dispersal of populations associated with the Epigravettian culture. This often involves analyzing similar products to compare how they performed. 21, 199 (2020). Nowadays, we take it for granted that these features exist, but the integrity of those products is, in fact, a labor of love. Gansauge, M., Aximu-Petri, A., Nagel, S. & Meyer, M. Manual and automated preparation of single-stranded DNA libraries for the sequencing of DNA from ancient biological remains and other sources of highly degraded DNA. Tina Huang Is A Member Of . Ecol. Photo by Sara Kurfe on Unsplash 1. University Universit Chouaib Doukkali; . Karmin, M. et al. Previous studies identified two different genetic compositions in Magdalenian-associated individualsthe GoyetQ2 cluster including central-western European genomes dated to around 15ka (from France, Belgium and Germany), and the ancestry of the El Mirn individual from Spain4,14 from around 19ka. The Magdalenian culture was widely distributed in southwestern, western and central Europe after the LGM33. Initial Upper Palaeolithic humans in Europe had recent Neanderthal ancestry, A genomic Neolithic time transect of hunter-farmer admixture in central Poland, Palaeo-Eskimo genetic ancestry and the peopling of Chukotka and North America, A genetic history of the pre-contact Caribbean, Ancient genomes from the last three millennia support multiple human dispersals into Wallacea, Ancient DNA reveals admixture history and endogamy in the prehistoric Aegean, A 23,000-year-old southern Iberian individual links human groups that lived in Western Europe before and after the Last Glacial Maximum, Genetic history from the Middle Neolithic to present on the Mediterranean island of Sardinia, Ancient DNA from mastics solidifies connection between material culture and genetics of mesolithic huntergatherers in Scandinavia, https://github.com/stschiff/sequenceTools, https://reich.hms.harvard.edu/allen-ancient-dna-resource-aadr-downloadable-genotypes-present-day-and-ancient-dna-data, https://edmond.mpdl.mpg.de/dataset.xhtml?persistentId=doi:10.17617/3.Y1KJMF, https://haproh.readthedocs.io/en/latest/hapROH_with_contamination.html, https://doi.org/10.1007/978-94-017-7206-8_6, https://doi.org/10.1038/s41559-023-01987-0. In this episode we go through a couple really superb resumes that you should model yours after. This suggests that between the Early/Middle and Late Gravettian there was an east-to-west expansion of the Vstonice-associated ancestry that reached central-western Europe and created a longitudinal admixturecline between those two genetically distinct pre-LGM populations. Huang, Y. 4a). Genetics 192, 10651093 (2012). Tina Huang, a data scientist currently working at a FAANG (Facebook, Amazon, Apple, Netflix, and Google Alphabet) company. Nature 592, 253257 (2021). This suggests a very small recent effective population size, estimated to be in the order of around 70 individuals (Supplementary Table 2), causing the low genetic diversity in Sicilian Epigravettian hunter-gatherers. The grouping of Epigravettian-associated populations is shown with the same colour in a. 3b). My name is Tina Huang and I'm a data scientist at a FAANG company. Learn with a sense of purpose. Genomic structure in Europeans dating back at least 36,200 years. This process allowed us to assign an ancestral or derived haplogroup for covered branches, and to make corrections to calls in cases where, for instance, a more derived haplogroup was called because of residual ancient damage (C-to-T or G-to-A mismatches) in terminal read positions at diagnostic SNPs98 (Supplementary Data 1.A). 35, 15471549 (2018). PubMed Central Liet. 4b and Supplementary Data 3.C). use of cookies We provide a systematic description of the genomic transformations that hunter-gatherer groups experienced from the early Upper Palaeolithic onwards across western and central Eurasia and how those are possibly linked to cultural and climatic changes. & Ringbauer, H. hapCon: estimating contamination of ancient genomes by copying from reference haplotypes. Citing . All remains were sampled with the approval of the institutions responsible for the analysis of archaeological material. We love meeting interesting people and making new friends. Cosimo Posth, He Yu, Ayshin Ghalichi, Hlne Rougier, Isabelle Crevecoeur, Yilei Huang, Harald Ringbauer, Adam B. Rohrlach, Kathrin Ngele, Vanessa Villalba-Mouco, Rita Radzeviciute, Tiago Ferraz, Alexander Stoessel, Rezeda Tukhbatova, Dorothe G. Drucker, Martina Lari, Alessandra Modi, Stefania Vai, Tina Saupe, Christiana L. Scheib, Giulio Catalano, Luca Pagani, Sahra Talamo, Helen Fewlass, Laurent Klaric, Andr Morala, Mathieu Ru, Stphane Madelaine, Laurent Crpin, Jean-Baptiste Caverne, Emmy Bocaege, Stefano Ricci, Francesco Boschin, Priscilla Bayle, Bruno Maureille, Foni Le Brun-Ricalens, Jean-Guillaume Bordes, Gregorio Oxilia, Eugenio Bortolini, Olivier Bignon-Lau, Grgory Debout, Michel Orliac, Antoine Zazzo, Vitale Sparacello, Elisabetta Starnini, Luca Sineo, Johannes van der Plicht, Laure Pecqueur, Gildas Merceron, Graldine Garcia, Jean-Michel Leuvrey, Coralie Bay Garcia, Asier Gmez-Olivencia, Marta Potowicz-Bobak, Dariusz Bobak, Mona Le Luyer, Paul Storm, Claudia Hoffmann, Jacek Kabaciski, Tatiana Filimonova, Svetlana Shnaider, Natalia Berezina, Borja Gonzlez-Rabanal, Manuel R. Gonzlez Morales, Ana B. Marn-Arroyo, Beln Lpez, Carmen Alonso-Llamazares, Annamaria Ronchitelli, Caroline Polet, Ivan Jadin, Nicolas Cauwe, Joaquim Soler, Neus Coromina, Isaac Ruf, Richard Cottiaux, Geoffrey Clark, Lawrence G. Straus, Marie-Anne Julien, Silvia Renhart, Dorothea Talaa, Stefano Benazzi, Matteo Romandini, Luc Amkreutz, Herv Bocherens, Christoph Wiing, Sbastien Villotte, Javier Fernndez-Lpez de Pablo, Magdalena Gmez-Puche, Marco Aurelio Esquembre-Bebia, Pierre Bodu, Liesbeth Smits, Bndicte Souffi, Rimantas Jankauskas, Justina Kozakait, Christophe Cupillard, Hartmut Benthien, Kurt Wehrberger, Ralf W. Schmitz, Susanne C. Feine, Tim Schler, Corinne Thevenet, Dan Grigorescu, Friedrich Lth, Andreas Kotula, Henny Piezonka, Franz Schopper, Ji Svoboda, Sandra Szelov, Andrey Chizhevsky, Aleksandr Khokhlov, Nicholas J. Conard, Frdrique Valentin, Katerina Harvati, Patrick Semal, Bettina Jungklaus, Alexander Suvorov, Rick Schulting, Vyacheslav Moiseyev, Kristiina Mannermaa, Alexandra Buzhilova, Thomas Terberger, David Caramelli, Eveline Altena, Wolfgang Haak, Johannes Krause.